A point mutation in the extracellular domain of KIT promotes tumorigenesis of mast cells via ligand-independent auto-dimerization. [electronic resource]
Producer: 20160303Description: 9775 p. digitalISSN:- 2045-2322
- Amino Acid Substitution
- Animals
- Cell Line
- Cell Transformation, Neoplastic -- genetics
- Dogs
- Mast Cells -- metabolism
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Phosphorylation -- genetics
- Point Mutation
- Protein Multimerization -- genetics
- Protein Structure, Tertiary
- Proto-Oncogene Proteins c-kit -- genetics
- Stem Cell Factor -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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