Pharmacologically Increasing Mdm2 Inhibits DNA Repair and Cooperates with Genotoxic Agents to Kill p53-Inactivated Ovarian Cancer Cells. [electronic resource]
Producer: 20160606Description: 1197-205 p. digitalISSN:- 1557-3125
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- therapeutic use
- Apoptosis
- Cell Line, Tumor
- Cell Proliferation
- Cisplatin -- administration & dosage
- Comet Assay
- DNA Breaks, Double-Stranded -- drug effects
- DNA Damage
- DNA Repair
- Etoposide -- administration & dosage
- Female
- Fibroblasts -- metabolism
- HEK293 Cells
- Humans
- Imidazoles -- administration & dosage
- Mice
- Mice, Transgenic
- Mutagens
- Ovarian Neoplasms -- genetics
- Piperazines -- administration & dosage
- Proto-Oncogene Proteins c-mdm2 -- genetics
- Tumor Suppressor Protein p53 -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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