In a methotrexate-induced model of intestinal mucositis, olmesartan reduced inflammation and induced enteropathy characterized by severe diarrhea, weight loss, and reduced sucrose activity. [electronic resource]
Producer: 20160519Description: 746-52 p. digitalISSN:- 1347-5215
- Angiotensin II Type 1 Receptor Blockers -- pharmacology
- Animals
- Anti-Inflammatory Agents -- pharmacology
- Antimetabolites, Antineoplastic -- adverse effects
- Diarrhea -- chemically induced
- Disease Models, Animal
- Imidazoles -- pharmacology
- Inflammation -- chemically induced
- Interleukin-1beta -- metabolism
- Intestinal Mucosa -- drug effects
- Intestine, Small -- drug effects
- Male
- Methotrexate -- adverse effects
- Mucositis -- chemically induced
- Neoplasms -- drug therapy
- Olmesartan Medoxomil -- pharmacology
- Rats, Wistar
- Sucrose -- metabolism
- Tetrazoles -- pharmacology
- Tumor Necrosis Factor-alpha -- metabolism
- Weight Loss -- drug effects
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Publication Type: Journal Article
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