A novel water-soluble benzothiazole derivative BD926 inhibits human activated T cell proliferation by down-regulating the STAT5 activation. [electronic resource]
Producer: 20160517Description: 36-43 p. digitalISSN:- 1879-0712
- Animals
- Benzimidazoles -- chemistry
- Benzothiazoles -- chemistry
- Cell Proliferation -- drug effects
- Cells, Cultured
- Cyclin D3 -- metabolism
- Cyclin-Dependent Kinase 6 -- metabolism
- Cytokines -- metabolism
- Dermatitis, Allergic Contact -- immunology
- Dinitrofluorobenzene
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Down-Regulation
- Female
- G1 Phase Cell Cycle Checkpoints -- drug effects
- Humans
- Immunosuppressive Agents -- chemistry
- Indazoles -- chemistry
- Lymphocyte Activation -- drug effects
- Mice, Inbred BALB C
- Phosphorylation
- STAT5 Transcription Factor -- metabolism
- Signal Transduction -- drug effects
- Solubility
- T-Lymphocytes -- drug effects
- Water -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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