Sequential cancer mutations in cultured human intestinal stem cells. [electronic resource]
Producer: 20160602Description: 43-7 p. digitalISSN:- 1476-4687
- Aneuploidy
- Animals
- CRISPR-Cas Systems
- Child
- Child, Preschool
- Colorectal Neoplasms -- genetics
- Female
- Genes, APC
- Genes, p53 -- genetics
- Heterografts
- Humans
- Imidazoles
- Intercellular Signaling Peptides and Proteins -- metabolism
- Intestinal Mucosa -- metabolism
- Intestines -- pathology
- Mice
- Middle Aged
- Mutagenesis, Site-Directed
- Mutation -- genetics
- Neoplasm Invasiveness -- genetics
- Neoplasm Transplantation
- Organoids -- metabolism
- Piperazines
- Proto-Oncogene Proteins p21(ras) -- genetics
- Smad4 Protein -- deficiency
- Stem Cell Niche -- physiology
- Stem Cells -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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