Arsenic trioxide synergistically potentiates the cytotoxic effect of fludarabine in chronic lymphocytic leukemia cells by further inactivating the Akt and ERK signaling pathways. [electronic resource]
Producer: 20150727Description: 243-8 p. digitalISSN:- 1090-2104
- Adult
- Aged
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Arsenic Trioxide
- Arsenicals -- pharmacology
- Drug Synergism
- Enzyme Inhibitors -- pharmacology
- Female
- Growth Inhibitors -- pharmacology
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy
- MAP Kinase Signaling System -- drug effects
- Male
- Middle Aged
- Oxides -- pharmacology
- Proto-Oncogene Proteins c-akt -- antagonists & inhibitors
- Signal Transduction -- drug effects
- Tumor Cells, Cultured
- Vidarabine -- analogs & derivatives
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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