Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. [electronic resource]
Producer: 20160106Description: 8566 p. digitalISSN:- 2045-2322
- Acetylation
- Animals
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins -- deficiency
- Cells, Cultured
- Disease Models, Animal
- Gastrointestinal Diseases -- etiology
- Gene Expression Regulation -- drug effects
- Glycogen Synthase Kinase 3 -- antagonists & inhibitors
- Humans
- Intestines -- cytology
- Mice
- Mice, Knockout
- Pyridines -- pharmacology
- Pyrimidines -- pharmacology
- Radiation Injuries, Experimental
- Radiation Tolerance -- drug effects
- Radiation, Ionizing
- Radiation-Protective Agents -- pharmacology
- Radiotherapy -- adverse effects
- Receptors, G-Protein-Coupled -- metabolism
- Stem Cells -- drug effects
- Tumor Suppressor Protein p53 -- genetics
- Tumor Suppressor Proteins -- deficiency
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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