Structural and functional screening in human induced-pluripotent stem cell-derived cardiomyocytes accurately identifies cardiotoxicity of multiple drug types. [electronic resource]
Producer: 20150703Description: 51-60 p. digitalISSN:- 1096-0333
- Antineoplastic Agents -- classification
- Biomarkers -- metabolism
- Cell Survival -- drug effects
- Cells, Cultured
- Dose-Response Relationship, Drug
- Heart Diseases -- chemically induced
- High-Throughput Screening Assays
- Humans
- Induced Pluripotent Stem Cells -- drug effects
- Lipid Metabolism -- drug effects
- Molecular Structure
- Myocytes, Cardiac -- drug effects
- Oxidative Stress -- drug effects
- Reactive Oxygen Species -- metabolism
- Reproducibility of Results
- Risk Assessment
- Structure-Activity Relationship
- Time Factors
- Toxicity Tests -- methods
- Troponin I -- metabolism
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Publication Type: Journal Article
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