Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancer-associated fibroblasts abrogates pancreatic tumour chemoresistance. [electronic resource]
Producer: 20160225Description: 735-53 p. digitalISSN:- 1757-4684
- Adaptor Proteins, Signal Transducing -- antagonists & inhibitors
- Adenocarcinoma -- drug therapy
- Animals
- Antineoplastic Agents -- pharmacology
- Carcinoma, Pancreatic Ductal -- drug therapy
- Cell Cycle Proteins
- Cells, Cultured
- Deoxycytidine -- analogs & derivatives
- Disease Models, Animal
- Drug Resistance
- Fibroblasts -- metabolism
- Heterografts
- Humans
- Mice, Nude
- Phosphoproteins -- antagonists & inhibitors
- Somatostatin -- analogs & derivatives
- TOR Serine-Threonine Kinases -- antagonists & inhibitors
- Treatment Outcome
- Gemcitabine
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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