Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach. [electronic resource]
Producer: 20150805Description: 3133-43 p. digitalISSN:- 1528-0020
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Bridged Bicyclo Compounds, Heterocyclic -- pharmacology
- Cell Cycle Checkpoints -- drug effects
- Cell Line, Tumor
- Disease Models, Animal
- Drug Screening Assays, Antitumor
- GTP Phosphohydrolases -- genetics
- Germinal Center Kinases
- Humans
- Leukemia -- drug therapy
- Membrane Proteins -- genetics
- Mice
- Mutation
- Protein Kinase Inhibitors -- pharmacology
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Proto-Oncogene Proteins c-akt -- metabolism
- Pyrimidinones -- pharmacology
- Signal Transduction -- drug effects
- Small Molecule Libraries
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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