Overexpression of mutant Ptch in rhabdomyosarcomas is associated with promoter hypomethylation and increased Gli1 and H3K4me3 occupancy. [electronic resource]
Producer: 20160301Description: 9113-24 p. digitalISSN:- 1949-2553
- Animals
- Azacitidine -- analogs & derivatives
- CpG Islands
- DNA Methylation -- drug effects
- Decitabine
- Embryonic Development -- genetics
- Gene Expression Regulation, Neoplastic -- drug effects
- Genes, Tumor Suppressor
- Gestational Age
- Heterozygote
- Histones -- metabolism
- Kruppel-Like Transcription Factors -- metabolism
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Knockout
- Models, Genetic
- Mutation
- Neoplasm Proteins -- biosynthesis
- Patched Receptors
- Patched-1 Receptor
- Polymorphism, Single Nucleotide
- Promoter Regions, Genetic -- genetics
- Protein Processing, Post-Translational
- Receptors, Cell Surface -- biosynthesis
- Rhabdomyosarcoma -- genetics
- Signal Transduction
- Zinc Finger Protein GLI1
No physical items for this record
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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