Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway. [electronic resource]
Producer: 20160809Description: 1555-84 p. digitalISSN:- 1177-8881
- Antineoplastic Agents -- chemistry
- Apoptosis -- drug effects
- Autophagy -- drug effects
- Azepines -- chemistry
- Cell Cycle -- drug effects
- Cell Proliferation -- drug effects
- Cell Survival -- drug effects
- Dose-Response Relationship, Drug
- Drug Screening Assays, Antitumor
- Humans
- MAP Kinase Signaling System -- drug effects
- Mitochondria -- drug effects
- Mitogen-Activated Protein Kinases -- antagonists & inhibitors
- Molecular Structure
- Phosphatidylinositol 3-Kinases -- metabolism
- Phosphoinositide-3 Kinase Inhibitors
- Protein Kinase Inhibitors -- chemistry
- Proto-Oncogene Proteins c-akt -- antagonists & inhibitors
- Pyrimidines -- chemistry
- Reactive Oxygen Species -- metabolism
- Structure-Activity Relationship
- TOR Serine-Threonine Kinases -- antagonists & inhibitors
- Tumor Cells, Cultured
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Publication Type: Journal Article
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