Activation of extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) by free fatty acid receptor 1 (FFAR1/GPR40) protects from palmitate-induced beta cell death, but plays no role in insulin secretion. [electronic resource]
Producer: 20151221Description: 1537-45 p. digitalISSN:- 1421-9778
- Aniline Compounds -- pharmacology
- Animals
- Apoptosis -- drug effects
- Blotting, Western
- Cell Line, Tumor
- Flavonoids -- pharmacology
- Glucose -- pharmacology
- Insulin -- metabolism
- Insulin Secretion
- Insulin-Secreting Cells -- cytology
- MAP Kinase Kinase 1 -- antagonists & inhibitors
- Mice
- Mitogen-Activated Protein Kinase 1 -- metabolism
- Mitogen-Activated Protein Kinase 3 -- metabolism
- Palmitates -- toxicity
- Phenylpropionates -- pharmacology
- Phosphorylation -- drug effects
- Receptors, G-Protein-Coupled -- agonists
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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