Activation of peroxisome proliferator-activated receptor α induces lysosomal biogenesis in brain cells: implications for lysosomal storage disorders. [electronic resource]
Producer: 20150619Description: 10309-24 p. digitalISSN:- 1083-351X
- Animals
- Astrocytes -- cytology
- Autophagy -- drug effects
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors -- genetics
- Brain -- cytology
- Gemfibrozil -- pharmacology
- Gene Expression Regulation
- Humans
- Lipid Metabolism -- drug effects
- Lysosomes -- drug effects
- Mice
- Neurons -- cytology
- PPAR alpha -- agonists
- PPAR gamma -- genetics
- PPAR-beta -- genetics
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
- Primary Cell Culture
- Promoter Regions, Genetic
- Protein Binding
- Retinoid X Receptor alpha -- genetics
- Signal Transduction
- Transcription Factors -- genetics
- Tretinoin -- pharmacology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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