CDK4/6 Inhibitor PD 0332991 Sensitizes Acute Myeloid Leukemia to Cytarabine-Mediated Cytotoxicity. [electronic resource]
Producer: 20150714Description: 1838-45 p. digitalISSN:- 1538-7445
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Cell Line
- Cyclin-Dependent Kinase 4 -- antagonists & inhibitors
- Cyclin-Dependent Kinase 6 -- antagonists & inhibitors
- Cytarabine -- pharmacology
- DNA Damage -- drug effects
- DNA Replication -- drug effects
- HEK293 Cells
- HL-60 Cells
- Humans
- Leukemia, Myeloid, Acute -- drug therapy
- Mice, Inbred NOD
- Mice, SCID
- Phosphorylation -- drug effects
- Piperazines -- pharmacology
- Protein Kinase Inhibitors -- pharmacology
- Proto-Oncogene Proteins c-pim-1 -- genetics
- Pyridines -- pharmacology
- S Phase -- drug effects
- Transcription, Genetic -- drug effects
- Tumor Cells, Cultured
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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