Perturbation of ribosome biogenesis drives cells into senescence through 5S RNP-mediated p53 activation. [electronic resource]
Producer: 20151125Description: 1310-23 p. digitalISSN:- 2211-1247
- Animals
- Cell Cycle Proteins -- antagonists & inhibitors
- Cell Nucleolus -- metabolism
- Cells, Cultured
- Cellular Senescence
- Humans
- MCF-7 Cells
- Mice
- Nuclear Proteins -- antagonists & inhibitors
- Proto-Oncogene Proteins c-mdm2 -- genetics
- RNA Interference
- RNA, Ribosomal, 5S -- metabolism
- RNA, Small Interfering -- metabolism
- RNA-Binding Proteins
- Ribosomal Proteins -- antagonists & inhibitors
- Ribosomes -- metabolism
- Transcriptional Activation
- Tumor Suppressor Protein p53 -- metabolism
- Up-Regulation
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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