The discovery of macrocyclic XIAP antagonists from a DNA-programmed chemistry library, and their optimization to give lead compounds with in vivo antitumor activity. [electronic resource]
Producer: 20150526Description: 2855-61 p. digitalISSN:- 1520-4804
- Animals
- Antineoplastic Agents -- chemistry
- Breast -- drug effects
- Breast Neoplasms -- drug therapy
- Caspase 3 -- metabolism
- Cell Line, Tumor
- Crystallography, X-Ray
- Drug Discovery
- Female
- Gene Library
- Humans
- Macrocyclic Compounds -- chemistry
- Mice
- Models, Molecular
- X-Linked Inhibitor of Apoptosis Protein -- antagonists & inhibitors
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Publication Type: Journal Article
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