A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. [electronic resource]
Producer: 20150501Description: 248-55 p. digitalISSN:- 1546-170X
- Animals
- Carrier Proteins -- antagonists & inhibitors
- Cryopyrin-Associated Periodic Syndromes -- drug therapy
- Disease Models, Animal
- Encephalomyelitis, Autoimmune, Experimental -- drug therapy
- Furans
- Heterocyclic Compounds, 4 or More Rings -- pharmacology
- Humans
- Indenes
- Inflammasomes -- antagonists & inhibitors
- Inflammation
- Interleukin-1beta -- drug effects
- Mice
- Multiple Sclerosis
- NLR Family, Pyrin Domain-Containing 3 Protein
- Sulfonamides
- Sulfones -- pharmacology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
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