Upregulated expression of STIM2, TRPC6, and Orai2 contributes to the transition of pulmonary arterial smooth muscle cells from a contractile to proliferative phenotype. [electronic resource]
Producer: 20150723Description: C581-93 p. digitalISSN:- 1522-1563
- Animals
- Calcium -- metabolism
- Calcium Channel Blockers -- pharmacology
- Calcium Channels -- biosynthesis
- Calcium Channels, L-Type -- metabolism
- Calcium Signaling -- physiology
- Cell Dedifferentiation
- Cell Proliferation
- Cells, Cultured
- Hypertension, Pulmonary -- metabolism
- Male
- Membrane Glycoproteins -- biosynthesis
- Mice
- Mice, Inbred C57BL
- Muscle Contraction -- physiology
- Muscle, Smooth, Vascular -- cytology
- Myocytes, Smooth Muscle -- cytology
- Nifedipine -- pharmacology
- ORAI2 Protein
- Pulmonary Artery -- cytology
- RNA Interference
- RNA, Small Interfering
- Rats
- Rats, Sprague-Dawley
- Stromal Interaction Molecule 2
- TRPC Cation Channels -- biosynthesis
- TRPC6 Cation Channel
- Transforming Growth Factor beta -- pharmacology
- Vascular Remodeling -- physiology
- Vascular Resistance
- Vasoconstriction
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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