Cell cycle deregulation and mosaic loss of Ext1 drive peripheral chondrosarcomagenesis in the mouse and reveal an intrinsic cilia deficiency. [electronic resource]
Producer: 20150720Description: 210-8 p. digitalISSN:- 1096-9896
- Animals
- Bone Neoplasms -- genetics
- Carcinogenesis -- genetics
- Cell Cycle -- genetics
- Cell Proliferation -- genetics
- Cell Transformation, Neoplastic -- genetics
- Chondrocytes -- physiology
- Chondrosarcoma -- genetics
- Cilia -- genetics
- Cyclin-Dependent Kinase Inhibitor p16 -- genetics
- Disease Models, Animal
- Integrases -- genetics
- Mice, Transgenic
- Mosaicism
- N-Acetylglucosaminyltransferases -- genetics
- Osteochondroma -- genetics
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53 -- genetics
- Exostosin 1
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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