Discovery of the first small-molecule opioid pan antagonist with nanomolar affinity at mu, delta, kappa, and nociceptin opioid receptors. [electronic resource]
Producer: 20160104Description: 646-57 p. digitalISSN:- 1948-7193
- Analgesics, Opioid -- chemistry
- Animals
- CHO Cells
- Cell Membrane -- drug effects
- Cricetulus
- Dose-Response Relationship, Drug
- Guanosine 5'-O-(3-Thiotriphosphate) -- chemistry
- Humans
- Models, Chemical
- Molecular Structure
- Narcotic Antagonists -- chemical synthesis
- Piperidines -- chemical synthesis
- Protein Binding
- Receptors, Opioid -- metabolism
- Receptors, Opioid, delta -- antagonists & inhibitors
- Receptors, Opioid, kappa -- antagonists & inhibitors
- Receptors, Opioid, mu -- antagonists & inhibitors
- Sulfur Radioisotopes -- chemistry
- Tetrahydroisoquinolines -- chemistry
- Transfection
- Nociceptin Receptor
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Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural
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