TM-233, a novel analog of 1'-acetoxychavicol acetate, induces cell death in myeloma cells by inhibiting both JAK/STAT and proteasome activities. [electronic resource]
Producer: 20150804Description: 438-46 p. digitalISSN:- 1349-7006
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Benzyl Alcohols -- chemistry
- Boronic Acids -- pharmacology
- Bortezomib
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Drug Resistance, Neoplasm -- drug effects
- G1 Phase Cell Cycle Checkpoints -- drug effects
- Humans
- Janus Kinase 2 -- antagonists & inhibitors
- Multiple Myeloma -- enzymology
- Myeloid Cell Leukemia Sequence 1 Protein -- biosynthesis
- NF-kappa B -- antagonists & inhibitors
- Proteasome Endopeptidase Complex -- metabolism
- Proteasome Inhibitors -- pharmacology
- Proto-Oncogene Proteins c-bcl-2 -- biosynthesis
- Pyrazines -- pharmacology
- Quantitative Structure-Activity Relationship
- STAT3 Transcription Factor -- antagonists & inhibitors
- bcl-X Protein -- biosynthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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