Neutrophil IL-1β processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux. [electronic resource]
Producer: 20150422Description: 1763-75 p. digitalISSN:- 1550-6606
- Animals
- Apoptosis Regulatory Proteins -- immunology
- Bacterial Proteins -- immunology
- Blotting, Western
- CARD Signaling Adaptor Proteins
- Carrier Proteins -- immunology
- Caspase 1 -- immunology
- Disease Models, Animal
- Enzyme Activation -- immunology
- Enzyme-Linked Immunosorbent Assay
- Eye Infections, Bacterial -- immunology
- Flow Cytometry
- Fluorescent Antibody Technique
- Humans
- Inflammasomes -- immunology
- Interleukin-1beta -- immunology
- Keratitis -- immunology
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- NLR Family, Pyrin Domain-Containing 3 Protein
- Neutrophils -- immunology
- Pneumococcal Infections
- Potassium -- metabolism
- Signal Transduction -- immunology
- Spectrophotometry, Atomic
- Streptolysins -- immunology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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