Statin-induced depletion of geranylgeranyl pyrophosphate inhibits cell proliferation by a novel pathway of Skp2 degradation. [electronic resource]
Producer: 20151125Description: 2889-902 p. digitalISSN:- 1949-2553
- Alkyl and Aryl Transferases -- antagonists & inhibitors
- Animals
- Antigens, CD
- Antineoplastic Agents -- pharmacology
- Cadherins -- genetics
- Cdh1 Proteins -- genetics
- Cell Proliferation -- drug effects
- Cyclin-Dependent Kinase Inhibitor p21 -- metabolism
- Cyclin-Dependent Kinase Inhibitor p27 -- metabolism
- Down-Regulation
- Genes, APC
- HeLa Cells
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors -- pharmacology
- Lovastatin -- pharmacology
- Mice
- NIH 3T3 Cells
- Neoplasms -- drug therapy
- Polyisoprenyl Phosphates -- metabolism
- Proteasome Endopeptidase Complex -- metabolism
- Proteolysis
- S-Phase Kinase-Associated Proteins -- genetics
- Signal Transduction -- drug effects
- Time Factors
- Transfection
- U937 Cells
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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