Biochemical factors in the selectivity of leucovorin rescue: selective inhibition of leucovorin reactivation of dihydrofolate reductase and leucovorin utilization in purine and pyrimidine biosynthesis by methotrexate and dihydrofolate polyglutamates. [electronic resource]
Producer: 19880304Description: 17-26 p. digitalISSN:- 0893-2751
- Antineoplastic Combined Chemotherapy Protocols
- Biological Transport
- Drug Administration Schedule
- Folic Acid Antagonists -- pharmacology
- Humans
- Leucovorin -- administration & dosage
- Methotrexate -- administration & dosage
- Neoplasms -- drug therapy
- Nucleosides -- administration & dosage
- Polyglutamic Acid -- metabolism
- Tetrahydrofolate Dehydrogenase -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review
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