Pharmacological inhibition of BACE1 impairs synaptic plasticity and cognitive functions. [electronic resource]
Producer: 20160101Description: 729-39 p. digitalISSN:- 1873-2402
- Amyloid Precursor Protein Secretases -- deficiency
- Amyloid beta-Peptides -- metabolism
- Animals
- Aspartic Acid Endopeptidases -- deficiency
- Brain -- anatomy & histology
- Cognition -- physiology
- Cognitive Dysfunction -- chemically induced
- Dendritic Spines -- drug effects
- Dose-Response Relationship, Drug
- Enzyme Inhibitors -- chemistry
- Exploratory Behavior -- drug effects
- Humans
- Maze Learning -- drug effects
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Peptide Fragments -- metabolism
- Pyramidal Cells -- drug effects
- Pyrimidines -- chemistry
- Pyrimidinones -- pharmacology
- Synaptic Potentials -- drug effects
- Thiazines -- chemistry
- Thiophenes -- pharmacology
- Time Factors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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