Discovery of novel 2,5-dioxoimidazolidine-based P2X(7) receptor antagonists as constrained analogues of KN62. [electronic resource]
Producer: 20150615Description: 2114-34 p. digitalISSN:- 1520-4804
- 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine -- analogs & derivatives
- Animals
- Arthritis, Experimental -- chemically induced
- Carrageenan -- toxicity
- Cattle
- Collagen Type II -- toxicity
- Drug Discovery
- Edema -- chemically induced
- Enzyme-Linked Immunosorbent Assay
- HEK293 Cells
- Humans
- Hydantoins -- chemistry
- Immunoblotting
- Inflammation -- chemically induced
- Interleukin-1beta -- metabolism
- Long-Term Potentiation
- Macrophages -- cytology
- Male
- Mice, Inbred DBA
- Molecular Structure
- Monocytes -- cytology
- Neuralgia -- drug therapy
- Purinergic P2X Receptor Antagonists -- chemistry
- Rats
- Rats, Sprague-Dawley
- Receptors, Purinergic P2X7 -- chemistry
- Structure-Activity Relationship
- Sulfonic Acids -- chemistry
- Tissue Distribution
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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