Carnosic acid sensitized TRAIL-mediated apoptosis through down-regulation of c-FLIP and Bcl-2 expression at the post translational levels and CHOP-dependent up-regulation of DR5, Bim, and PUMA expression in human carcinoma caki cells. [electronic resource]
Producer: 20151201Description: 1556-68 p. digitalISSN:- 1949-2553
- Abietanes -- administration & dosage
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Apoptosis Regulatory Proteins -- biosynthesis
- Bcl-2-Like Protein 11
- Breast Neoplasms -- drug therapy
- CASP8 and FADD-Like Apoptosis Regulating Protein -- biosynthesis
- Carcinoma, Hepatocellular -- drug therapy
- Carcinoma, Renal Cell -- drug therapy
- Cell Line, Tumor
- Down-Regulation -- drug effects
- Drug Synergism
- Female
- Humans
- Kidney Neoplasms -- drug therapy
- Liver Neoplasms -- drug therapy
- Membrane Proteins -- biosynthesis
- Mice
- Neoplasms -- drug therapy
- Plant Extracts -- administration & dosage
- Proto-Oncogene Proteins -- biosynthesis
- Proto-Oncogene Proteins c-bcl-2 -- biosynthesis
- Receptors, TNF-Related Apoptosis-Inducing Ligand -- biosynthesis
- TNF-Related Apoptosis-Inducing Ligand -- administration & dosage
- Transcription Factor CHOP -- metabolism
- Up-Regulation -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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