Activation of the nuclear receptor PPARδ is neuroprotective in a transgenic mouse model of Alzheimer's disease through inhibition of inflammation. [electronic resource]
Producer: 20160810Description: 7 p. digitalISSN:- 1742-2094
- Alzheimer Disease -- complications
- Amyloid beta-Peptides -- metabolism
- Amyloid beta-Protein Precursor -- genetics
- Animals
- Animals, Newborn
- Anti-Inflammatory Agents -- administration & dosage
- Calcium-Binding Proteins -- metabolism
- Cell Adhesion Molecules -- metabolism
- Cells, Cultured
- Complement C1q -- metabolism
- Complement C3 -- metabolism
- Disease Models, Animal
- Embryo, Mammalian
- Female
- Gene Expression Regulation -- drug effects
- Glial Fibrillary Acidic Protein -- metabolism
- Humans
- Inflammation -- drug therapy
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Microfilament Proteins -- metabolism
- PPAR delta -- metabolism
- Phosphopyruvate Hydratase -- metabolism
- Thiazoles -- administration & dosage
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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