Formulation of glutathione responsive anti-proliferative nanoparticles from thiolated Akt1 siRNA and disulfide-crosslinked PEI for efficient anti-cancer gene therapy. [electronic resource]
Producer: 20151120Description: 322-7 p. digitalISSN:- 1873-4367
- Animals
- Apoptosis -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cell Survival -- drug effects
- Colonic Neoplasms -- genetics
- Cross-Linking Reagents -- chemistry
- Disease Models, Animal
- Disulfides -- chemistry
- Genetic Therapy
- Glutathione -- chemistry
- Mice
- Mice, Inbred BALB C
- Nanoparticles -- chemistry
- Polyethyleneimine -- chemical synthesis
- Proto-Oncogene Proteins c-akt -- biosynthesis
- RNA, Small Interfering -- chemistry
- Sulfhydryl Compounds -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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