Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents. [electronic resource]
Producer: 20151103Description: 7642 p. digitalISSN:- 2045-2322
- Acetylcholine -- metabolism
- Administration, Oral
- Analgesics -- chemistry
- Animals
- Arachidonic Acids -- chemistry
- Binding Sites
- Brain -- metabolism
- Cannabinoid Receptor Antagonists -- pharmacology
- Carbamates -- chemistry
- Chromatography, High Pressure Liquid
- Crystallography, X-Ray
- Disease Models, Animal
- Electric Stimulation
- Endocannabinoids -- chemistry
- Enzyme Inhibitors -- chemistry
- Glycerides -- chemistry
- Hippocampus -- drug effects
- Humans
- Hydrolysis
- In Vitro Techniques
- Learning -- drug effects
- Long-Term Potentiation -- drug effects
- Mass Spectrometry
- Memory, Short-Term -- drug effects
- Mice
- Mice, Inbred C57BL
- Mice, SCID
- Monoacylglycerol Lipases -- antagonists & inhibitors
- Pain -- drug therapy
- Piperidines -- pharmacology
- Protein Structure, Tertiary
- Pyrazoles -- pharmacology
- Rimonabant
- Seizures -- drug therapy
- Sulfonamides -- chemistry
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Publication Type: Journal Article
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