22-S-Hydroxycholesterol protects against ethanol-induced liver injury by blocking the auto/paracrine activation of MCP-1 mediated by LXRα. [electronic resource]
Producer: 20150507Description: 710-20 p. digitalISSN:- 1096-9896
- Animals
- Autocrine Communication -- drug effects
- Binding Sites
- Cell Hypoxia
- Cells, Cultured
- Chemokine CCL2 -- genetics
- Cytoprotection
- Disease Models, Animal
- Ethanol
- Fatty Liver, Alcoholic -- metabolism
- Hepatocytes -- drug effects
- Hydroxycholesterols -- pharmacology
- Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism
- Kupffer Cells -- drug effects
- Lipogenesis -- drug effects
- Liver -- drug effects
- Liver X Receptors
- Male
- Mice, Inbred C57BL
- Orphan Nuclear Receptors -- antagonists & inhibitors
- Paracrine Communication -- drug effects
- Promoter Regions, Genetic
- Signal Transduction -- drug effects
- Transfection
- Up-Regulation
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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