Extracellular cyclophilin A activates platelets via EMMPRIN (CD147) and PI3K/Akt signaling, which promotes platelet adhesion and thrombus formation in vitro and in vivo. [electronic resource]
Producer: 20160412Description: 655-63 p. digitalISSN:- 1524-4636
- Animals
- Basigin -- blood
- Blood Platelets -- drug effects
- Carotid Artery Injuries -- blood
- Cell Degranulation -- drug effects
- Chlorides
- Cyclophilin A -- antagonists & inhibitors
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Ferric Compounds
- Fibrinolytic Agents -- pharmacology
- Humans
- Mice, Inbred C57BL
- Mice, Knockout
- Phosphatidylinositol 3-Kinases -- blood
- Platelet Adhesiveness -- drug effects
- Platelet Aggregation -- drug effects
- Platelet Aggregation Inhibitors -- pharmacology
- Proto-Oncogene Proteins c-akt -- blood
- Signal Transduction -- drug effects
- Thrombosis -- blood
- Time Factors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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