Feedback suppression of PI3Kα signaling in PTEN-mutated tumors is relieved by selective inhibition of PI3Kβ. [electronic resource]
Producer: 20150313Description: 109-22 p. digitalISSN:- 1878-3686
- Aniline Compounds -- pharmacology
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Cell Cycle -- drug effects
- Cell Line, Tumor
- Chromones -- pharmacology
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Mice
- Neoplasm Transplantation
- Neoplasms -- drug therapy
- PTEN Phosphohydrolase -- genetics
- Phosphoinositide-3 Kinase Inhibitors
- Protein Kinase Inhibitors -- pharmacology
- Signal Transduction -- drug effects
- Thiazoles -- pharmacology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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