A6V polymorphism of the human μ-opioid receptor decreases signalling of morphine and endogenous opioids in vitro. [electronic resource]
Producer: 20160105Description: 2258-72 p. digitalISSN:- 1476-5381
- Adenylyl Cyclase Inhibitors -- pharmacology
- Adenylyl Cyclases -- metabolism
- Analgesics, Opioid -- pharmacology
- Animals
- Buprenorphine -- pharmacology
- CHO Cells
- Cricetulus
- Dose-Response Relationship, Drug
- Enkephalin, Ala(2)-MePhe(4)-Gly(5)- -- pharmacology
- Fentanyl -- pharmacology
- G Protein-Coupled Inwardly-Rectifying Potassium Channels -- agonists
- Genotype
- Humans
- Ion Channel Gating -- drug effects
- Mitogen-Activated Protein Kinase 1 -- metabolism
- Mitogen-Activated Protein Kinase 3 -- metabolism
- Morphine -- pharmacology
- Phenotype
- Phosphorylation
- Polymorphism, Single Nucleotide
- Receptors, Opioid, mu -- agonists
- Signal Transduction -- drug effects
- Time Factors
- Transfection
- beta-Endorphin -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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