Checkpoint blockade immunotherapy relies on T-bet but not Eomes to induce effector function in tumor-infiltrating CD8+ T cells. [electronic resource]
Producer: 20151124Description: 116-24 p. digitalISSN:- 2326-6074
- Animals
- CD8-Positive T-Lymphocytes -- immunology
- Cell Line, Tumor
- Cytotoxicity, Immunologic -- immunology
- Gene Expression Regulation, Neoplastic -- immunology
- Immune Tolerance -- immunology
- Immunotherapy -- methods
- Leukemia, Experimental -- genetics
- Lymphocytes, Tumor-Infiltrating -- immunology
- Mice, Transgenic
- Neoplasm Transplantation
- T-Box Domain Proteins -- immunology
- T-bet Transcription Factor
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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