A dihydroindolizino indole derivative selectively stabilizes G-quadruplex DNA and down-regulates c-MYC expression in human cancer cells. [electronic resource]
Producer: 20150219Description: 129-40 p. digitalISSN:- 0006-3002
- Animals
- Antineoplastic Agents -- chemical synthesis
- Binding, Competitive
- Calorimetry
- Cell Line, Tumor
- Cell Movement -- drug effects
- Cell Proliferation -- drug effects
- DNA -- chemistry
- Down-Regulation -- drug effects
- G-Quadruplexes
- Gene Expression Regulation, Neoplastic -- drug effects
- HeLa Cells
- Humans
- Indoles -- chemical synthesis
- MCF-7 Cells
- Models, Chemical
- Molecular Structure
- Neoplasms -- genetics
- Proto-Oncogene Proteins c-myc -- genetics
- Reverse Transcriptase Polymerase Chain Reaction
- Spectrometry, Mass, Electrospray Ionization
- Spectrophotometry
- Transition Temperature -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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