Activation of the anticancer drugs cyclophosphamide and ifosfamide by cytochrome P450 BM3 mutants. [electronic resource]
Producer: 20170207Description: 182-92 p. digitalISSN:- 1879-3169
- Activation, Metabolic
- Antineoplastic Agents, Alkylating -- metabolism
- Bone Neoplasms -- drug therapy
- Cell Line, Tumor
- Cell Survival -- drug effects
- Cyclophosphamide -- metabolism
- Cytochrome P-450 CYP2B6 -- genetics
- Dose-Response Relationship, Drug
- Genotype
- Humans
- Hydroxylation
- Ifosfamide -- metabolism
- Kinetics
- Microsomes, Liver -- enzymology
- Mutation
- Osteosarcoma -- drug therapy
- Phenotype
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Publication Type: Journal Article
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