Combined inhibition of Chk1 and Wee1 as a new therapeutic strategy for mantle cell lymphoma. [electronic resource]
Producer: 20160328Description: 3394-408 p. digitalISSN:- 1949-2553
- Animals
- Antineoplastic Agents -- pharmacology
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins -- genetics
- Benzodiazepinones -- pharmacology
- CDC2 Protein Kinase
- Cell Cycle Checkpoints -- drug effects
- Cell Cycle Proteins -- antagonists & inhibitors
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Checkpoint Kinase 1
- Cyclin-Dependent Kinase 2 -- genetics
- Cyclin-Dependent Kinases -- genetics
- Dose-Response Relationship, Drug
- Drug Synergism
- Female
- Gene Expression Profiling
- Humans
- Inhibitory Concentration 50
- Lymphoma, Mantle-Cell -- drug therapy
- Mice, Nude
- Molecular Targeted Therapy
- Nuclear Proteins -- antagonists & inhibitors
- Protein Kinase Inhibitors -- pharmacology
- Protein Kinases -- genetics
- Protein-Tyrosine Kinases -- antagonists & inhibitors
- Pyrazoles -- pharmacology
- Pyrimidines -- pharmacology
- Pyrimidinones
- Time Factors
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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