Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues. [electronic resource]
Producer: 20150217Description: 7854-65 p. digitalISSN:- 1520-4995
- Antibiotics, Antineoplastic -- biosynthesis
- Bacterial Proteins -- antagonists & inhibitors
- Base Sequence
- Bioreactors
- Cell Line, Tumor
- Cell Survival -- drug effects
- Drug Design
- Gene Silencing
- Humans
- Macrolides -- chemistry
- Models, Biological
- Molecular Sequence Data
- Molecular Structure
- Multigene Family
- Mutant Proteins -- chemistry
- Neoplasms -- drug therapy
- Piperidones -- chemistry
- Polyketide Synthases -- antagonists & inhibitors
- Polyketides -- chemistry
- Protein Engineering
- Recombinant Proteins -- chemistry
- Stereoisomerism
- Streptomyces -- enzymology
- Structure-Activity Relationship
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Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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