The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model. [electronic resource]
Producer: 20150831Description: 69-82 p. digitalISSN:- 1860-7187
- Animals
- Binding Sites
- Cell Line
- Cell Proliferation -- drug effects
- Disease Models, Animal
- Dopaminergic Neurons -- drug effects
- Drug Evaluation, Preclinical
- Forkhead Box Protein O3
- Forkhead Transcription Factors -- metabolism
- Histone Deacetylase Inhibitors -- chemistry
- Humans
- MCF-7 Cells
- Molecular Docking Simulation
- Neuroprotective Agents -- chemistry
- Parkinson Disease -- drug therapy
- Protein Binding
- Protein Structure, Tertiary
- Pyrimidinones -- chemistry
- Rats
- Sirtuin 2 -- antagonists & inhibitors
- Structure-Activity Relationship
- Thiophenes -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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