A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation. [electronic resource]
Producer: 20150908Description: 191-206 p. digitalISSN:- 1520-6017
- Animals
- Cells, Cultured
- Computational Biology
- Cytochrome P-450 Enzyme System -- genetics
- Drug Evaluation, Preclinical -- methods
- Drugs, Investigational -- metabolism
- Gene Expression Profiling
- Gene Expression Regulation -- drug effects
- Gene Expression Regulation, Enzymologic -- drug effects
- Germany
- Humans
- Liver -- cytology
- Mice, Inbred C57BL
- Models, Biological
- Organ Specificity
- Pharmacology, Clinical -- methods
- Physiology, Comparative -- methods
- Species Specificity
- Specific Pathogen-Free Organisms
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Publication Type: Comparative Study; Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
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