Synthesis and pharmacologic characterization of an alkylating analogue (chlornaltrexamine) of naltrexone with ultralong-lasting narcotic antagonist properties. [electronic resource]
Producer: 19790523Description: 168-73 p. digitalISSN:- 0022-2623
- Alkylating Agents -- chemical synthesis
- Analgesics
- Animals
- Humans
- In Vitro Techniques
- Male
- Mice
- Molecular Conformation
- Morphine -- antagonists & inhibitors
- Morphine Dependence -- prevention & control
- Naloxone -- analogs & derivatives
- Naltrexone -- analogs & derivatives
- Narcotic Antagonists -- chemical synthesis
- Nitrogen Mustard Compounds -- chemical synthesis
- Rats
- Receptors, Opioid -- metabolism
- Time Factors
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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