Dual antiangiogenic inhibition: a phase I dose escalation and expansion trial targeting VEGF-A and VEGFR in patients with advanced solid tumors. [electronic resource]
Producer: 20150918Description: 215-24 p. digitalISSN:- 1573-0646
- Adult
- Aged
- Aged, 80 and over
- Angiogenesis Inhibitors -- administration & dosage
- Antibodies, Monoclonal, Humanized -- administration & dosage
- Antineoplastic Combined Chemotherapy Protocols -- adverse effects
- Bevacizumab
- Class I Phosphatidylinositol 3-Kinases
- Female
- Humans
- Male
- Middle Aged
- Mutation
- Neoplasms -- drug therapy
- Niacinamide -- administration & dosage
- PTEN Phosphohydrolase -- genetics
- Phenylurea Compounds -- administration & dosage
- Phosphatidylinositol 3-Kinases -- genetics
- Polymorphism, Single Nucleotide
- Proto-Oncogene Proteins -- genetics
- Receptors, Vascular Endothelial Growth Factor -- antagonists & inhibitors
- Sorafenib
- Tumor Suppressor Protein p53 -- genetics
- Vascular Endothelial Growth Factor A -- antagonists & inhibitors
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Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural
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