Discrepancies between FISH and immunohistochemistry for assessment of the ALK status are associated with ALK 'borderline'-positive rearrangements or a high copy number: a potential major issue for anti-ALK therapeutic strategies. [electronic resource]
Producer: 20150824Description: 238-244 p. digitalISSN:- 1569-8041
- Adenocarcinoma -- drug therapy
- Adenocarcinoma of Lung
- Adult
- Aged
- Aged, 80 and over
- Anaplastic Lymphoma Kinase
- Crizotinib
- Female
- Fluorescent Antibody Technique -- methods
- Gene Dosage -- genetics
- Gene Rearrangement
- Genetic Variation -- genetics
- Humans
- In Situ Hybridization, Fluorescence -- methods
- Lung Neoplasms -- drug therapy
- Male
- Middle Aged
- Protein Kinase Inhibitors -- therapeutic use
- Protein-Tyrosine Kinases -- analysis
- Proto-Oncogene Proteins -- analysis
- Proto-Oncogene Proteins c-met -- analysis
- Pyrazoles -- therapeutic use
- Pyridines -- therapeutic use
- Receptor Protein-Tyrosine Kinases -- analysis
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Publication Type: Journal Article
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