A novel BH3 mimetic efficiently induces apoptosis in melanoma cells through direct binding to anti-apoptotic Bcl-2 family proteins, including phosphorylated Mcl-1. [electronic resource]
Producer: 20151116Description: 161-70 p. digitalISSN:- 1755-148X
- Animals
- Antineoplastic Agents -- chemistry
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins -- metabolism
- Bcl-2-Like Protein 11
- Caspases -- metabolism
- Cell Line, Tumor
- Extracellular Signal-Regulated MAP Kinases -- metabolism
- Gossypol -- pharmacology
- Humans
- JNK Mitogen-Activated Protein Kinases -- metabolism
- Melanoma -- pathology
- Membrane Proteins -- metabolism
- Mice
- Mitochondria -- drug effects
- Myeloid Cell Leukemia Sequence 1 Protein -- metabolism
- Phosphorylation -- drug effects
- Proteolysis -- drug effects
- Proto-Oncogene Proteins -- metabolism
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- Signal Transduction -- drug effects
- Substrate Specificity -- drug effects
- bcl-2 Homologous Antagonist-Killer Protein -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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