Prednisone inhibits the IL-1β-induced expression of COX-2 in HEI-OC1 murine auditory cells through the inhibition of ERK-1/2, JNK-1 and AP-1 activity. [electronic resource]
Producer: 20150721Description: 1640-6 p. digitalISSN:- 1791-244X
- Animals
- Blotting, Western
- Cell Line
- Cyclooxygenase 2 -- genetics
- Dinoprostone -- metabolism
- Gene Expression Regulation, Enzymologic -- drug effects
- Glucocorticoids -- pharmacology
- Hair Cells, Auditory -- drug effects
- Hormone Antagonists -- pharmacology
- Interleukin-1beta -- pharmacology
- Mice
- Mifepristone -- pharmacology
- Mitogen-Activated Protein Kinase 1 -- antagonists & inhibitors
- Mitogen-Activated Protein Kinase 3 -- antagonists & inhibitors
- Mitogen-Activated Protein Kinase 8 -- antagonists & inhibitors
- Mitogen-Activated Protein Kinases -- antagonists & inhibitors
- Prednisone -- pharmacology
- Promoter Regions, Genetic -- genetics
- Receptors, Glucocorticoid -- antagonists & inhibitors
- Reverse Transcriptase Polymerase Chain Reaction
- Transcription Factor AP-1 -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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