A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation. [electronic resource]
Producer: 20150122Description: 1055-60 p. digitalISSN:- 1552-4469
- Animals
- Brain -- drug effects
- Cell Line
- Coculture Techniques
- Gene Expression
- HMGB1 Protein -- genetics
- HMGB2 Protein -- genetics
- Heterocyclic Compounds, 4 or More Rings -- pharmacology
- Inflammation -- chemically induced
- Lipopolysaccharides
- Male
- Mice
- Mice, Inbred C57BL
- Microglia -- drug effects
- Neuroimmunomodulation
- Neurons -- drug effects
- Neuroprotective Agents -- pharmacology
- Protein Binding
- Protein Processing, Post-Translational
- Tumor Necrosis Factor-alpha -- biosynthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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