A multi-parameter in vitro screen in human stem cell-derived cardiomyocytes identifies ponatinib-induced structural and functional cardiac toxicity. [electronic resource]
Producer: 20160105Description: 147-55 p. digitalISSN:- 1096-0929
- Actin Cytoskeleton -- drug effects
- Antineoplastic Agents -- toxicity
- Cell Death -- drug effects
- Cell Differentiation
- Cell Line
- Dose-Response Relationship, Drug
- Heart Diseases -- chemically induced
- Heart Rate -- drug effects
- Humans
- Imidazoles -- toxicity
- Induced Pluripotent Stem Cells -- drug effects
- Mitochondria, Heart -- drug effects
- Myocytes, Cardiac -- drug effects
- Oxidative Stress -- drug effects
- Protein Kinase Inhibitors -- toxicity
- Pyridazines -- toxicity
- Risk Assessment
- Signal Transduction -- drug effects
- Time Factors
- Toxicity Tests -- methods
- Troponin -- metabolism
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Publication Type: Journal Article
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