α-Mangostin from Cratoxylum arborescens demonstrates apoptogenesis in MCF-7 with regulation of NF-κB and Hsp70 protein modulation in vitro, and tumor reduction in vivo. [electronic resource]
Producer: 20150713Description: 1629-47 p. digitalISSN:- 1177-8881
- Animals
- Antineoplastic Agents, Phytogenic -- chemistry
- Apoptosis -- drug effects
- Breast Neoplasms -- drug therapy
- Cell Proliferation -- drug effects
- Cells, Cultured
- Clusiaceae -- chemistry
- Dose-Response Relationship, Drug
- Drug Screening Assays, Antitumor
- Female
- HSP70 Heat-Shock Proteins -- metabolism
- Humans
- MCF-7 Cells
- Mammary Neoplasms, Animal -- drug therapy
- Molecular Structure
- NF-kappa B -- metabolism
- Rats
- Rats, Sprague-Dawley
- Reactive Oxygen Species -- metabolism
- Structure-Activity Relationship
- Xanthones -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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